Wickham Micro are excited to announce their most recent publication on "The Importance of Testing for Pyrogens in Raw and In-Process Materials", written by Section Head of Endotoxin and Cytotoxicity Testing, Sophie Bell.
The article, published by International Biopharmaceutical Industry (IBI) in their December issue, discusses the effects pyrogens can have on humans and focuses on the three different methods used to test pyrogens as well as why such testing is compulsory within the pharmaceutical and medical device industry.
An excerpt of this article as follows:
Pyrogens are substances that can induce shock, fever or death with the most common type of pyrogen being the gram-negative bacteria-derived lipopolysaccharide or endotoxin.
There are currently three approved methods for the testing of pyrogenicity; the rabbit pyrogen test (RPT), the bacterial endotoxin test (BET) using limulus amoebocyte lysate (LAL) and the monocyte activation test (MAT). Both the BET and the MAT were developed to replace the rabbit pyrogen test in effort to reduce the number of animals used in pyrogen testing.